Osteoporotic Bone showed Enhanced Fracture Healing Response with Low Intensity Pulsed Ultrasound

Introduction: Most fractures in elderly are fragility fractures occurring in osteoporotic bones. Delayed in treatment may cause morbidity and mortality with many complications and social burdens. Our previous clinical study had shown that the use of low intensity pulsed ultrasound (LIPUS) could provide a beneficial effect on complex fracture. This promising efficacy was further consolidated through in vitro findings in which LIPUS stimulated the osteogenic activity of periosteal cell. With a poorer repair potential in osteoporotic bone fracture, a similar beneficial effect of LIPUS is, therefore, expected. In this study, the effects of LIPUS on fracture healings, and most importantly on the osteoporotic condition, were investigated.